Lupin acquired drug formulation developer Gavis Pharmaceuticals this week in a deal that gives it its first manufacturing site in the US. At least 1 percent of men have a curved penis. The most common symptom of penile curvature is discomfort or pain in the penis during sex. Usually the curve increases over a six-month period, then stops getting any more noticeable. Pain from inflammation with the curvature may go on for two to three months, but it always ends. Careful examination of the penis often reveals a scar that replaces the normal elastic tissue. The scar does not expand during penile erection, so the penis curves toward the side with the scar. Usually, a slight curve is not a problem. In some patients, however, the curvature may get in the way of sexual activity.
Like every grieving family member, I looked for someone to blame for my father’s death. But my dad’s doctors weren’t incompetent—on the contrary, his hospital physicians were smart, thoughtful, and hard-working. Nor is he dead because of indifferent nursing—without exception, his nurses were dedicated and compassionate. Nor from financial limitations—he was a Medicare patient, and the issue of expense was never once raised. There were no greedy pharmaceutical companies, evil health insurers, or other popular villains in his particular tragedy.
Kewal is the past President of All India Management Association (AIMA), Past Vice President of Organization of Pharmaceutical Producers in India (OPPI), past Committee Member of the Confederation of Indian Industry (CII), a past member of the Managing Committee of the Bombay Chamber of Commerce & Industry and the Chairman of the Pharmaceutical Committee – ASSOCHAM. He is presently Governing Board of the prestigious IIM (Indian Institute of Management,) Raipur. He has also been a member of the Governing Boards of IIM, Ahmadabad and independent director and Chairman of audit committee at Alfa Lava ltd. Kewal is a qualified Management Accountant and Company Secretary and has a Masters Degree in Commerce. He has completed the Pfizer Leadership Development Program from Harvard University and the Senior Management Development Program from IIM, Ahmadabad. He has also done a course on Marketing Strategy from Columbia Business School.
The effect of avanafil on warfarin pharmacokinetics and pharmacodynamics was evaluated in a double blind, randomized, placebo- controlled, two-way crossover study. Twenty-four healthy male volunteers were randomized to receive either 200 mg avanafil or matching placebo for 9 days. On Day 3 of each period, volunteers received a single 25 mg warfarin. Pharmacokinetics of R- and S- warfarin, PT, and INR prior to warfarin dosing and up to 168 hours after warfarin administration were compared. Platelet aggregation prior to warfarin dosing and up to 24 hours after warfarin administration were compared. PT, INR, and platelet aggregation did not change with avanafil administration: 23.1 sec, 2.2, and 75.5%, respectively. Co-administration with avanafil resulted in an approximate 1.6% increase in AUC0-inf and 5.2% decrease in Cmax of S-warfarin.
The basic screen consists of serum testosterone and prolactin measurements. The specific testosterone assay to be obtained is debated. 15 , 17 Testosterone is predominately protein-bound and is influenced by a variety of clinical conditions. It is secreted in a diurnal manner with a peak in the morning. Normal testosterone levels gradually decline with advancing age. An age-adjusted, first-morning, free testosterone level is probably the most accurate measure. 17 If the initial testosterone level is low, follow-up studies should include luteinizing hormone and follicle-stimulating hormone levels to differentiate testicular from hypothalamic-pituitary dysfunction. Elevated prolactin levels warrant further evaluation, including hypothalamic-pituitary imaging.
This content is owned by the AAFP. A person viewing it online may make one printout of the material and may use that printout only for his or her personal, non-commercial reference. This material may not otherwise be downloaded, copied, printed, stored, transmitted or reproduced in any medium, whether now known or later invented, except as authorized in writing by the AAFP. Contact [email protected] for copyright questions and/or permission requests.
Flibanserin is one of the forerunners. Initially developed as an antidepressant, it was found to have little effect on people’s mood. However, women enrolled on clinical trials of the drug started to report an unexpected side-effect: feeling more interested in sex.
I am very proud of Northwest Community College and excited about its future. I have enjoyed my time here so much and am truly grateful to have worked with such a talented and dedicated group of people. It has been a great privilege to serve this institution and the communities of Northwest British Columbia,” wrote Henning in a message to the NWCC community.